| Acronym | Definition |
|---|
| SPB | Spb Software House |
| SPB | State Personnel Board |
| SPB | Saint Petersburg |
| SPB | Silicon Package Board |
| SPB | Spring Predictability Barrier Climatology (El Niño Southern Oscillation forecast) |
| SPB | Shortest Path Bridging (computer networking) |
| SPB | Southern Pine Beetle |
| SPB | Spindle Pole Body (biology, biochemistry) |
| SPB | Synchronous Pipeline Burst |
| SPB | Stored Procedure Builder |
| SPB | Sea Plane Base |
| SPB | Special Pathogens Branch (Centers for Disease Control) |
| SPB | Schynige Platte Bahn (German; Swiss mountain railway) |
| SPB | Split Pillow Block (engineering) |
| SPB | Strategic Policy Branch (Health Canada) |
| SPB | Survivor Benefit Plan (US DoD) |
| SPB | Simple Payback (engineering economics) |
| SPB | Security Policy Board |
| SPB | State Postal Bureau (China) |
| SPB | Summative Project Brief |
| SPB | State Parole Board (New Jersey) |
| SPB | Sociedade Portuguesa de Bioquímica (Portuguese Society of Biochemistry) |
| SPB | Specialty Products Business (various organizations) |
| SPB | Secret Policeman's Ball |
| SPB | St Thomas Island, VI, USA - Seaplane Base (Airport Code) |
| SPB | Scénario Paintball (French: Scenario Paintball; online paintball forum) |
| SPB | SP Balasubramanyam (Indian singer) |
| SPB | Special Projects Branch (National Institutes of Health) |
| SPB | San Pawl il-Bahar (postal locality, Malta) |
| SPB | Semi Prismatic type B (LNG storage tank) |
| SPB | Strategic Planning Board |
| SPB | Strategic Planning and Budget (Office) |
| SPB | Sphere Packing Bound |
| SPB | Selling Price Breakdown (OEM industry) |
| SPB | Sripathi Panditaradhyula Balasubramaniam (Indian singer) |
| SPB | Shanghai Price Bureau |
| SPB | Shifted Polynomial Basis |
| SPB | Senior Professional Band (General Electric) |
| SPB | Shanghai Sports Bureau |
| SPB | Single-Point Background |
| SPB | Ship Protected Barrier (US Navy) |
| SPB | Special Purpose Bodies (various organizations) |
| SPB | Super Paint Brawl (community forum) |