| Acronym | Definition |
|---|
| SMK | Sekolah Menengah Kebangsaan (Malay: National Secondary Schools) |
| SMK | Smoke |
| SMK | Statens Museum for Kunst (Denmark) |
| SMK | Smoker |
| SMK | Scarecrow and Mrs. King (TV series) |
| SMK | Sekolah Menengah Kejuruan (Bahasa, Indonesia school) |
| SMK | Super Mario Kart (video game) |
| SMK | Security Master Key |
| SMK | Service Master Key (encryption) |
| SMK | Sierra Match King |
| SMK | Statsministerens Kontor |
| SMK | Slagsmålsklubben (Swedish band) |
| SMK | Svenska Missionskyrkan (Covenant Church of Sweden) |
| SMK | Showa Musen Kogyo (Japan) |
| SMK | Software Migration Kit |
| SMK | Shared Management Knowledge |
| SMK | Strana Maïarskej Koalície (Party of the Hungarian Coalition, Slovakia) |
| SMK | St. Michael, Alaska (Airport Code) |
| SMK | Sergius Mironovitch Kirov (Soviet tank) |
| SMK | Socialiniu Mokslu Kolegija (Lithuanian: College of Social Sciences) |
| SMK | System Multipurpose Key |
| SMK | Shelter Management Kit |
| SMK | Soins Mère Kangourou (French: Kangaroo Mother Care) |
| SMK | Saiva Mangaiyar Kalagam (Hindu Women's Society; Sri Lanka) |
| SMK | Slätte Motionsklubb (Swedish Athletic Clubb) |