| Acronym | Definition |
|---|
| SESAME | Single European Sky Implementation Programme (Eurocontrol) |
| SESAME | Second European Stratospheric Arctic and Mid-Latitude Experiment |
| SESAME | Stop Educator Sexual Abuse, Misconduct, and Exploitation |
| SESAME | Synchrotron Radiation for Experimental Science and Applications in the Middle East |
| SESAME | Secure European System for Applications in a Multivendor Environment |
| SESAME | Satellite Experiments Simultaneous with Antarctic Measurements |
| SESAME | Seminars for Elementary Specialists and Mathematics Educators |
| SESAME | Severe Environmental Storm and Mesoscale Experiment |
| SESAME | Standardization in Europe on Semantical Aspects of Medicine |
| SESAME | Selected Essential Item Stockage for Availability Methodology |
| SESAME | Surface Electrical Sounding and Acoustic Monitoring Experiment (ROSETTA Lander spacecraft) |
| SESAME | Second European Stratospheric and Middle Latitude Experiment (University of Cambridge UK) |