| Acronym | Definition |
|---|
| SFO | San Francisco |
| SFO | San Francisco, CA, USA - San Francisco International Airport (airport code) |
| SFO | Serious Fraud Office (UK) |
| SFO | Secular Franciscan Order |
| SFO | Sector Field Office |
| SFO | Single Family Office |
| SFO | Stocks, Futures and Options (magazine) |
| SFO | Shockwave Flash Object |
| SFO | Scottish Fiddle Orchestra (UK) |
| SFO | Société Française d'Ophtalmologie |
| SFO | Solicitation for Offers |
| SFO | Société Française d'Orchidophilie (French) |
| SFO | Strategy Focused Organization (Balanced Scorecard Collaborative) |
| SFO | Space Flight Operations (US NASA) |
| SFO | Structural and Functional Organization |
| SFO | Senior Federal Official |
| SFO | Sales Field Officer (various companies) |
| SFO | Senior FEMA (Federal Emergency Management Association) Official |
| SFO | Senior First Officer |
| SFO | Street Fighter Online (gaming) |
| SFO | Support for Others (USACE) |
| SFO | Statutory Funding Objective (UK) |
| SFO | Skole Fritids Ordning (in Norway; after school childcare) |
| SFO | Specialist Firearms Officer (England) |
| SFO | Scholarship Funding Organization |
| SFO | San Francisco (Operations) Office (Department of Energy) |
| SFO | Simulated Flame-Out |
| SFO | Sex for One |
| SFO | Senior Fire Officer |
| SFO | Sindikat Financnih Organizacij (Slovenian: Syndicate of Financial Organizations) |
| SFO | Squad Five O (band) |
| SFO | Starfleet Operations |
| SFO | Supervised Flight Operations (aviation) |
| SFO | Strathmere Festival Orchestra (Strathmere, NJ) |
| SFO | Satellite Field Office |
| SFO | Striking Fixed Objects |
| SFO | Sample Frequency Offset |
| SFO | Signal Flow Optimization |