| Acronym | Definition |
|---|
| SPASM | Société Parisienne d'Aide à la Santé Mentale (French: Parisian Society of Mental Health Assistance; est. 1959) |
| SPASM | Scalable Parallel Short-Range Molecular Dynamics (molecular-dynamics analysis software) |
| SPASM | Sketch Planning Analysis Spreadsheet Model |
| SPASM | Subscriber Parameter Administration Security Mechanism |
| SPASM | Single Pass Assembler (IBM mainframe assembler) |
| SPASM | Sane People Against Sailor Moon (anti-Sailor Moon organization) |
| SPASM | Society for the Prevention of Asinine Student Movements |
| SPASM | System Performance & Activity Software Monitor |