| Acronym | Definition |
|---|
| RISC | Reduced Instruction Set Computer |
| RISC | Reduced Instruction Set Computing |
| RISC | Research Institute for Symbolic Computation (Linz, Austria) |
| RISC | RNA Induced Silencing Complex (ribonucleoprotein complex involved in mRNA degradation) |
| RISC | Retail Installment Sales Contract |
| RISC | Reduced Instruction Set Code |
| RISC | Regional Interagency Steering Committee (FEMA/Federal Response Plan) |
| RISC | Regulatory Information Service Center (OMB) |
| RISC | Rhode Island Supreme Court (judiciary) |
| RISC | Risk Information Support Center |
| RISC | Responsible Internet Service Companies |
| RISC | Risk Information Sharing Consortium (National League of Cities) |
| RISC | Radiology Information System Consortium |
| RISC | Research Group on Instability in Coronary Artery Disease |
| RISC | Regional Intelligence Support Center |
| RISC | Reduced Instruction Set Class |
| RISC | Risk Institute for the Support of Communication |
| RISC | Repository for Individuals of Special Concern (US FBI) |
| RISC | Rural Industries Service Centre (India) |
| RISC | Runway Incursion Severity Classification (ICAO) |
| RISC | Restraint Information System Collection (Pennsylvania Department of Education) |
| RISC | Raffles Institution Science Club (Raffles Institution; Singapore) |
| RISC | Rhode Island Striper Club |