| Acronym | Definition |
|---|
| SOTB | Silicon on Thin Buried Oxide (semiconductors) |
| SOTB | Speed on the Beat (hip-hop) |
| SOTB | South Of The Border |
| SOTB | Sex On The Beach (a mixed drink) |
| SOTB | Spirit of Texas Bank (various locations) |
| SOTB | Shadow of the Beast (video game) |
| SOTB | Spit Out the Bone |
| SOTB | Slaughter of the Bluegrass (band) |
| SOTB | Sword of the Berserk (video game) |
| SOTB | Somewhere over the Rainbow (song) |
| SOTB | Sign of the Beaver (book by Elizabeth George Speare) |
| SOTB | Sound of the Braves (William R. Boone High School; Orlando, FL) |
| SOTB | Sweat of the Brow (copyright doctrine) |
| SOTB | Souls Of The Bleach (gaming clan) |
| SOTB | Sword of the Bloodsworn (Everquest gaming) |
| SOTB | Son of the Bird (band) |
| SOTB | Sunday Oliseh Tribute Band |
| SOTB | Secretary's Office, Transportation Branch (US Navy) |
| SOTB | Straight Off the Block (band) |
| SOTB | Surgery or the Bomb (UK band) |