| Acronym | Definition |
|---|
| SHE | Safety, Health, Environment |
| SHE | Sexual Health Education |
| SHE | Secondary Heat Exchanger |
| SHE | Self Heating Effect |
| SHE | Sector Head for the Exposed Source |
| SHE | Supercritical Helium |
| SHE | Selina, Hebe, Ella (band) |
| SHE | Scottish Higher Education |
| SHE | Standard Hydrogen Electrode |
| SHE | South Hialeah Elementary (Florida) |
| SHE | Syrian Hamster Embryo (mutagenics) |
| SHE | Sexual Homicide Exchange (advocacy and investigative website for sex killings) |
| SHE | Self-Help Enterprises |
| SHE | See Her Empowered (blog) |
| SHE | Society for Human Ecology |
| SHE | Sidetracked Home Executive |
| SHE | Sentinel Health Event (toxicology) |
| SHE | Super Heavy Element |
| SHE | Safe, Healthy, and Empowered |
| SHE | Super Head End |
| SHE | Subretinal Hyperreflective Exudation (eye health) |
| SHE | Shenyang, China - Shenyang (Airport Code) |
| SHE | Shrink, Hide, Embody (design principle) |
| SHE | Seductive Human Erotica (Tech N9ne song) |
| SHE | Spontaneous Human Explosion |
| SHE | Sequential Hardware Equivalence |
| SHE | System Hydrologique European |