S2
| Acronym | Definition |
|---|---|
| S2 | Sims 2 (game) |
| S2 | Secondary 2 (various locations) |
| S2 | Socom 2 (gaming) |
| S2 | Intelligence Officer (US Army) |
| S2 | Super Solenoid (Evangelion) |
| S2 | Smackdown 2 (Playstation game) |
| S2 | Intel Office (USMC) |
| S2 | Shut Up and Sit Down |
| S2 | Sleep Mode 2 (partial-sleep computer power-down state) |