| Acronym | Definition |
|---|
| SEN | Senior |
| SEN | Senator |
| SEN | Special Educational Needs (UK education system) |
| SEN | Sensitivity (Groundwater Modeling Systems) |
| SEN | Senegal (ISO Country code) |
| SEN | Statement of Educational Needs (UK) |
| SEN | Sony Entertainment Network |
| SEN | Sistema Eléctrico Nacional (Spanish: National Electric System; various locations) |
| SEN | Submerged Entry Nozzle (steel manufacturing) |
| SEN | Save Energy Now (various locations) |
| SEN | Sustainable Energy Network (various locations) |
| SEN | Social Entertainment Network |
| SEN | System Event Notification |
| SEN | Software Engineering Notebook |
| SEN | Sociedad Española de Neurología (Spanish Society of Neurology) |
| SEN | Solidarity Economy Network |
| SEN | Software Engineering Notes |
| SEN | Southern Energy Network (climate change advocacy; various locations) |
| SEN | State Enrolled Nurse |
| SEN | Student Environment Network (Canada) |
| SEN | Sports Entertainment Network |
| SEN | Small Extension Node |
| SEN | Satellite Education Network |
| SEN | Secretary of Energy Notice |
| SEN | Société des Eaux du Nord (French: Northern Waters Company; est. 1912) |
| SEN | subependymal nodule |
| SEN | Staredit Network (gaming) |
| SEN | standard enteral nutrition |
| SEN | Scalp-Ear-Nipple Syndrome |
| SEN | System Evaluation Network |
| SEN | System Engineering Note |