| Acronym | Definition |
|---|
| SCO | Santa Cruz Operation |
| SCO | Scotland |
| SCO | Shanghai Cooperation Organization |
| SCO | Swiss Cooperation Office (various locations) |
| SCO | Strategic Capabilities Office (US DoD) |
| SCO | State Controller’s Office |
| SCO | Scottish Chamber Orchestra (UK) |
| SCO | Servizio Centrale Operativo (Italian: Central Operational Service) |
| SCO | Shop cum Office (real estate; India) |
| SCO | Steel Can Opener (appliance) |
| SCO | Service Civique Obligatoire (French: Mandatory Civic Service) |
| SCO | Synchronous Connection Oriented Link |
| SCO | Score File |
| SCO | Set Synchronous Connection Oriented |
| SCO | St. Christopher Ottilie (New York) |
| SCO | Synthetic Crude Oil |
| SCO | Sharable Content Object |
| SCO | State Coordinating Officer (FEMA) |
| SCO | Special Counsel's Office (US DOJ) |
| SCO | Second Chance Offer (bids) |
| SCO | Senior Care Options |
| SCO | System Center Online (Microsoft) |
| SCO | Senior Commercial Officer (US foreign service) |
| SCO | Supply Chain Optimization |
| SCO | Squadron Commander |
| SCO | School Community Organization (various locations) |
| SCO | Synchronous Connection-Oriented Link (Bluetooth) |
| SCO | Senior Contracting Official (US Army) |
| SCO | Second Class Object (computing) |
| SCO | Self Check Out |
| SCO | Surface Contaminated Object |
| SCO | Sertoli Cell-Only |
| SCO | Social Change Organization |
| SCO | St. Charles Operations (petrochemical manufacturing; Louisiana) |
| SCO | Special Communication Organization (Pakistan) |
| SCO | Screening Coordination Office (US FEMA) |
| SCO | Sporting Club de l'Ouest (Angers, France soccer club) |
| SCO | Senior Credit Officer (banking) |
| SCO | State Classification Office (various states) |
| SCO | Special Compliance Officer (International Traffic in Arms Regulations) |
| SCO | Show Cause Order (legal summons) |
| SCO | Supracondylar Femur Osteotomies |
| SCO | SpaceCowboy Online (online gaming) |
| SCO | Southern Cycling Operations |
| SCO | Seasonal Conservation Officer (law enforcement) |
| SCO | Sales Contracting Officer |
| SCO | Sport Compact Only (various locations) |
| SCO | Saskatchewan College of Opticians (Canada) |
| SCO | Senior Correctional Officer (Australia) |
| SCO | Systems Control Officer |
| SCO | Senior Civilian Official |
| SCO | Senior Court Officer |
| SCO | Successor Contracting Officer |
| SCO | Service Certifying Organization |
| SCO | Safety Code Officer |
| SCO | Scholarship Coordination Office |
| SCO | Soft Corporate Offer |
| SCO | Sub-Control Office |
| SCO | Summary Court Officer |
| SCO | Secondary Control Officer |
| SCO | Specialist Coalition of Ontario |
| SCO | Supreme Court of Ontario |
| SCO | Société Canadienne d'Ophthalmologie (Canadian Ophthalmological Society) |
| SCO | System Control Officer |
| SCO | Self-Consistent Orbital |
| SCO | Safety Condition for Operation |
| SCO | Senior Canadian Officer (Canada) |
| SCO | Sub-Carrier Oscillator |
| SCO | Searchlight Control Officer |
| SCO | Selective Contingency Options |
| SCO | State Cleanup Order |
| SCO | Single-Cell Optimum |
| SCO | Signals Communications Officer |
| SCO | structure-conduct-outcomes |
| SCO | System/Secondary Control Officer |
| SCO | Systems Compliance Officer (various companies) |
| SCO | Statistical Control Office |
| SCO | Shipboard-Controlled Intercept |
| SCO | Space Control Officer |
| SCO | Social Compliance Officer (human resources) |
| SCO | Scope Change Operator |
| SCO | Santa Cruz Observatory (Spain) |