| Acronym | Definition |
|---|
| APE | Alternative Press Expo |
| APE | Attestato Di Prestazione Energetica (Italian: Certificate Of Energy Performance) |
| APE | Adapted Physical Education |
| APE | Accords de Partenariat Économique (French) |
| APE | Association des Parents d'Elèves (French: Association of Parents of Students; various locations) |
| APE | Allocation Parentale d'Éducation (French: child-raising allowance) |
| APE | Available Potential Energy (meteorology) |
| APE | Absolute Pointing Error |
| APE | All Paths Explorer |
| APE | Application Protocols Entities |
| APE | Application Performance Explorer |
| APE | Advanced Product Editor |
| APE | All Purpose Electronic Computer |
| APE | Automated Performance Enhancement |
| APE | Absolute Pitch Encoding |
| APE | Actual Parameter Expression |
| APE | Asynchronous Processing Element |
| APE | Application Engineering |
| APE | Annual Premium Equivalent (insurance) |
| APE | Area of Potential Effect |
| APE | Artists' Project Earth (UK) |
| APE | Aeropyrum Pernix |
| APE | Activité Principale Exercée (French) |
| APE | Assessment, Planning and Evaluation (various locations) |
| APE | Antígeno Prostático Específico (Spanish: Prostate Specific Antigen) |
| APE | Agir pour l'Environnement (French: Action for the Environment) |
| APE | Association for the Protection of the Environment |
| APE | Activité Principale de l'Entreprise |
| APE | Acute Pulmonary Embolism |
| APE | Against Primate Experiments |
| APE | Ammunition Peculiar Equipment |
| APE | Automated Production Equipment |
| APE | Arnold Palmer Enterprises (sports) |
| APE | Alkyl Phenol Ethoxylate |
| APE | Analyse et Politique Economiques (French: Economic Analysis and Policy; educational program) |
| APE | Average Percent Error (statistics) |
| APE | Annual Physical Examination |
| APE | Application Performance Explorer (Microsoft) |
| APE | Advanced Placement English |
| APE | Agency to Prevent Evil (from Lancelot Link, Secret Chimp TV show) |
| APE | Big Action Performance Ensemble (Gainesville, FL) |
| APE | Aurora Photography Experiment |
| APE | Advanced Process Equipment |
| APE | Annual Performance Evaluation |
| APE | Animal Project Editor (Zoo Tycoon game) |
| APE | Automatisme Protection Electronique (French: Automatic Electronic Protection; security company) |
| APE | Advanced Production Engineering |
| APE | Aerosol Photoemission |
| APE | American Piledriving Equipment, Inc |
| APE | Army Program Element (used in Army funding documents) |
| APE | Advances in Policy Enforcement (workshop) |
| APE | Alternative Primate Evolution (geocaching promotion) |
| APE | Area Project Engineer |
| APE | Always Pray Everyday |
| APE | Army Preliminary Evaluation |
| APE | Antenna Pointing Electronics |
| APE | Allocation Perte d'Emploi (French: Allowance for Loss of Employment) |
| APE | Asymptotic Phasefront Extraction |
| APE | Alternate Property Editor (Borland Software) |
| APE | Attitude Processing Electronics |
| APE | Apparatus, Personnel, Equipment (firefighting) |
| APE | Action Plan Element |
| APE | Application Protocols Entity |
| APE | Attitude and Power Electronic |
| APE | All Purpose Employee |
| APE | Aerial Port Element |
| APE | Antenna Positioning Equipment |
| APE | Advocates for Primate Empowerment |
| APE | Auto-Covariance Preserving Estimator |
| APE | Associate Pastor Emeritus (religious office or title) |
| APE | Agent-initiated Underwriting Evaluator (insurance) |
| APE | Association Fédérale Internationale de la Presse Eurafricaine (French) |
| APE | Annual Planning Estimate |
| APE | Apreto Peto i Exploto |
| APE | Annotated Points-to Escape (graph) |
| APE | Angus Promotional Enterprises (Canada) |