SPFI
| Acronym | Definition |
|---|---|
| SPFI | Summary of Performance and Financial Information (US DHHS) |
| SPFI | Sequential Port Fuel Injection |
| SPFI | Single Point Fuel Injection (vehicle engine technology) |
| SPFI | Spotsylvania Preservation Foundation Inc. (Spotsylvania, VA) |
| SPFI | Single Particle Fluorescence Imaging (biochemistry) |
| SPFI | Stochastic Processes in Finance and Insurance (New Zealand) |
| SPFI | Surface Protected Flexible Insulation |