SPFS
| Acronym | Definition |
|---|---|
| SPFS | Simple Parallel File System |
| SPFS | Scotch Parallel File System |
| SPFS | Scalable Parallel File System |
| SPFS | Special Programme for Food Security |
| SPFS | Surface Plasmon Fluorescence Spectroscopy |
| SPFS | South Pacific Forum Secretariat (now Pacific Islands Forum Secretariat; Suva, Fiji) |
| SPFS | Spastic Pelvic Floor Syndrome (gastroenterology) |
| SPFS | School Performance Feedback System |
| SPFS | Smallest Possible Feature Set |
| SPFS | Spectrum Protect File System (software) |