| Acronym | Definition |
|---|
| SPIRE | String Processing and Information Retrieval (International Symposium) |
| SPIRE | Spectral and Photometric Imaging Receiver (Cardiff University; School of Physics and Astronomy; UK) |
| SPIRE | School of Politics and International Relations (University College Dublin, Ireland) |
| SPIRE | Special Programs in Religious Education |
| SPIRE | Shared Primary Information Resource Environment (UK licensing system) |
| SPIRE | Spider Reconstruction Engine |
| SPIRE | South Pacific Institute of Renewable Energy |
| SPIRE | Southern Paranormal Investigations Research & Education |