| Acronym | Definition |
|---|
| SPK | Speaker |
| SPK | Stiftung Preussischer Kulturbesitz (German: Prussian Cultural Heritage Foundation) |
| SPK | Spokane (Washington) |
| SPK | Sistem Pengurusan Kualiti (Malay: Quality Management System) |
| SPK | Slipknot (band) |
| SPK | Storage Protection Key |
| SPK | Software Package |
| SPK | Spice Toolkit |
| SPK | Single Pack |
| SPK | Sermaye Piyasasi Kurulu |
| SPK | Summer Program for Kids (New York University) |
| SPK | Salt, Pepper, Ketchup (condiments) |
| SPK | Synthetic Paraffinic Kerosene (fuel) |
| SPK | Simultaneous Pancreas-Kidney Transplantation |
| SPK | Secret Provision for Kira (manga) |
| SPK | Sour Patch Kids (candy) |
| SPK | Some People's Kids |
| SPK | Sozialistisches Patienten Kollektiv |
| SPK | Soda Pop Krew (skateboarding; Salt Lake City, UT) |
| SPK | System for Population Kinetics |
| SPK | System Protection Kit |
| SPK | Special Provision for Kira (anime) |
| SPK | Single Point Keying |
| SPK | South Pacific Division-Sacramento District (USACE) |
| SPK | Spacecraft and Planet Kernel (US NASA) |
| SPK | Superficial Punctate Keratitis/Keratopathy |
| SPK | Surgical Penis Kilinik (band) |
| SPK | Single Point Kill |
| SPK | Swenson, Perer & Kontos (law firm; Pittsburgh, PA) |
| SPK | Summit Point Kart (motorsports park; West Virginia) |
| SPK | Spacecraft and Target Ephemeris Kernel |