| Acronym | Definition |
|---|
| TOPS | Taking Off Pounds Sensibly |
| TOPS | The Opportunity to Shine |
| TOPS | Time Out for Parents (childcare program) |
| TOPS | Total Operating System |
| TOPS | To Promote Safety |
| TOPS | Test of Performance Strategies (sports psychology) |
| TOPS | Tip-Over Protection Structure (earth-moving machinery) |
| TOPS | Transaction Online Processing System (US Navy) |
| TOPS | Tuition Opportunity Program for Students |
| TOPS | Traffic Operator Position System |
| TOPS | Team Oriented Problem Solving |
| TOPS | Toshiba Personal Computer System (Japan) |
| TOPS | Treatment Outcome Prospective Study |
| TOPS | Toward Other Planetary Systems |
| TOPS | Transportation Operational Personal Property Standard System |
| TOPS | Total Operations Processing System (British Rail) |
| TOPS | Tour Operators' Program of Safety |
| TOPS | Total Operations Per Second |
| TOPS | Time Sharing Operating System |
| TOPS | Taylor Opportunity Program for Students (Louisiana) |
| TOPS | Task Order Procurement System (Alaska) |
| TOPS | Tera Operations Per Second |
| TOPS | Theoretical Operations Per Second (computing speed) |
| TOPS | The Officer Placement Service |
| TOPS | Travel Order Processing System |
| TOPS | Teacher Opportunities to Promote Science |
| TOPS | Transistorized Operational Phone System (US NASA) |
| TOPS | Terascale Optimal PDE Simulation |
| TOPS | Thermodynamic Ocean Prediction System |
| TOPS | Technological Opportunities to Increase the Proliferation Resistance of Global Civilian Nuclear Power Systems (NERAC) |
| TOPS | Thermoelectric Outer Planet Spacecraft (NASA/JPL) |
| TOPS | Theory of Organismal Problem Solving |
| TOPS | Technical Operations and Production Services |
| TOPS | Technical Order Page Supplement |
| TOPS | Transparent Optical Packet Switching |
| TOPS | Technology Opportunity Showcase |
| TOPS | Tuberculosis Outreach and Prevention Services |
| TOPS | Total Ocean Profiling System |
| TOPS | Task Oriented Practices (Bellcore) |
| TOPS | Training Opportunity Services |
| TOPS | Team Osteopathic Physicals for Students |
| TOPS | Turbine Overload Protection System |
| TOPS | The Over Volunteering Prevention System (drug trial database; UK) |
| TOPS | The Ozarks Paranormal Society (Eldridge, MO) |
| TOPS | Tactical Onboard Processing System |
| TOPS | Total Operating Paperless System |
| TOPS | Talented Offering in the Programmes of Sciences |
| TOPS | Telephone On-Line Processing System (University of New Orleans) |
| TOPS | Tactical Optical Projection System |
| TOPS | Throughput Optimal Packet-Length-Selection (Rule) |
| TOPS | Theater Operations Simulation |
| TOPS | Travel Card Operator Services (Sprint) |
| TOPS | Time-sensitive Operational Planning System |
| TOPS | Toll Operation Position Station |
| TOPS | Tactical Operation Support |
| TOPS | Technical and Office Protocol Suite |
| TOPS | The Oregon Paranormal Society |
| TOPS | Team Oriented Production System |
| TOPS | Total Online Processing System (billing) |
| TOPS | Third Orbit Power Systems (Tustin, CA) |