| Acronym | Definition |
|---|
| SPLC | Southern Poverty Law Center |
| SPLC | Student Press Law Center (nonprofit organization dedicated to providing legal help and information to the student media and journalism educators) |
| SPLC | Samsung Printer Language Color |
| SPLC | Software Product Line Conference |
| SPLC | Splice |
| SPLC | Standard Point Location Code |
| SPLC | Stahl, Pequignot, Lorenz, Calame (Swiss law firm) |
| SPLC | Scalable Parallel Libraries Conference |
| SPLC | St Peters Lutheran College (Queensland, Australia) |
| SPLC | South Perth Learning Centre (South Perth, Australia) |
| SPLC | Saver Plus Lighting Corporation |
| SPLC | Security Privacy and Legacy Committee |