| Acronym | Definition |
|---|
| SPO | System(s) Project Office |
| SPO | System(s) Program Office |
| SPO | Single Purpose Outlet (electrical wiring) |
| SPO | Single Point of Failure (key system component) |
| SPO | San Pedro (Amtrak station code; San Pedro, CA) |
| SPO | Schizosaccharomyces Pombe |
| SPO | Strategic Planning Officer (various locations) |
| SPO | Sharepoint Online (software) |
| SPO | State Procurement Office (various locations) |
| SPO | Senior Programme Officer |
| SPO | Strategic Plan Objectives (various locations) |
| SPO | Senior Planning Officer (various organizations) |
| SPO | Service Parts Operations (General Motors) |
| SPO | Secondary Public Offering |
| SPO | Seoul Philharmonic Orchestra |
| SPO | Shanghai Philharmonic Orchestra |
| SPO | Slovak Philharmonic Orchestra |
| SPO | Student Police Officer |
| SPO | Sales Promotion Office |
| SPO | Sales Performance Optimization |
| SPO | Senior Patrol Officer (US government) |
| SPO | Standard Pascal Object |
| SPO | Security Police Officer |
| SPO | Special Order (used in retail stores operation) |
| SPO | Supplier Purchase Order |
| SPO | State Purchasing Officer (various locations) |
| SPO | Special Police Officer |
| SPO | Sendai Philharmonic Orchestra |
| SPO | Stoker Petty Officer (UK) |
| SPO | Srpski Pokret Obnove (Serbian: Serbian Renewal Movement; political party created in 1990 in Serbia-Yugoslavia) |
| SPO | Senate Press Office (Georgia) |
| SPO | Sektorowe Programy Operacyjne (Polish: Sectoral Operational Program) |
| SPO | Statutory Publications Office (UK) |
| SPO | Slaithwaite Philharmonic Orchestra (UK) |
| SPO | Structure, Process and Outcome (healthcare evaluation) |
| SPO | Special Projects Office |
| SPO | Spare Parts Order |
| SPO | Shuttle Projects Office (US NASA) |
| SPO | Strategic Planning Office (various locations) |
| SPO | Second Party Opinion (various companies) |
| SPO | Space Program Office |
| SPO | Smith-Peterson Osteotomy (surgical procedure) |
| SPO | Single-Pilot Operation (aviation; various organizations) |
| SPO | Shore Patrol Officer (US Navy) |
| SPO | Social Policy Obligations |
| SPO | Serviço de Psicologia e Orientação |
| SPO | Solution Partner Organization (Hewlett-Packard) |
| SPO | Student Professional Organization (Temple University; Philadelphia, PA) |
| SPO | Solar Polar Orbiter |
| SPO | Sales Prevention Officer |
| SPO | Subject, Predicate, Object (query language) |
| SPO | Support Operations Officer |
| SPO | Service Provision Option |
| SPO | Shape Preferred Orientation |
| SPO | Sacramento Peak Observatory (Sunspot, NM) |
| SPO | Specific Personal Objective |
| SPO | Sub Post Office |
| SPO | Storage Product Operations (EMC) |
| SPO | Supervisory Police Officer (Pakistan) |
| SPO | Stop Payment Order |
| SPO | Strengthening Participatory Organizations (Pakistan) |
| SPO | Sponsored Projects Officer |
| SPO | Saint Paul's Outreach |
| SPO | Sociedade Portuguesa de Ovnilogia (Portuguese Society for Research and Communication of Knowledge concerning UFO) |
| SPO | Smart Pasture Operation (agriculture) |
| SPO | Scarborough Philharmonic Orchestra (Canada) Scarborough Philharmonic Orchestra Scarborough Philharmonic Orchestra (Canada) |
| SPO | Specialist, Inspector of Naval Material (US Navy) |
| SPO | Sheffield Philharmonic Orchestra (UK) |
| SPO | Special Project Officer |
| SPO | Systematic Payout |
| SPO | Software Product Outsourcing |
| SPO | Sacheries Plastiques de l'Ouest (French: Plastic Bags of the West) |
| SPO | Summit Planning Organization |
| SPO | Surrey Philharmonic Orchestra (UK) |
| SPO | Systematic Payout Option |
| SPO | Short Period Oscillation |
| SPO | Spacelab Projects Office (NASA) |
| SPO | Student Publication Office (De La Salle-College of Saint Benilde; Philippines) |
| SPO | Shimizu Philharmonic Orchestra |
| SPO | Sourcing Process Outsourcing (business process outsourcing of candidate research services) |
| SPO | Sphincter-Preserving Operation (rectal surgery procedure) |
| SPO | Sagamihara Philharmonic Orchestra |
| SPO | Sarajevo Philharmonic Orchestra |
| SPO | Signal Property Office |
| SPO | Safety Project Office |
| SPO | Security and Plans Office/Officer |
| SPO | Shortest Path Oblivious (optical networking algorithm) |
| SPO | Security Payment Order |
| SPO | Security and Plans Operations |
| SPO | Seminary Post Office |
| SPO | Section Panel Operator |
| SPO | Security and Protection Officer |
| SPO | Sausage Peppers and Onions |
| SPO | Service Platform Operations (Sprint) |
| SPO | Single-Periodic Oscillation |
| SPO | Strategic Performance Objectives |
| SPO | Special Program Office/Officer |
| SPO | Super Pimp Online |
| SPO | Sewage Plant Operator |
| SPO | Standard Payment Order (financial services) |
| SPO | Supreme Poetical Orator (rapper) |