| Acronym | Definition |
|---|
| UPR | Union Populaire Républicaine (French political party) |
| UPR | Upper |
| UPR | Universal Periodic Review (UN Human Rights Council) |
| UPR | University of Puerto Rico |
| UPR | Unia Polityki Realnej (Polish political party) |
| UPR | unfolded protein response |
| UPR | Union Pacific Railroad |
| UPR | User Profile Repository |
| UPR | Unsaturated Polyester Resin |
| UPR | Usual Place of Residence |
| UPR | Unconditional Positive Regard |
| UPR | Unearned Premium Reserve (insurance) |
| UPR | Union for Progress and Renewal (Guinea) |
| UPR | Unité Pédagogique Régionale (French: Regional Educational Unit) |
| UPR | Upper Pipe Ram |
| UPR | United Piston Ring (various locations) |
| UPR | Uniform Progress Report (US government) |
| UPR | Union Patronale Régionale (French: Regional Employers' Union; France) |
| UPR | Upper Principal Representation |
| UPR | User Preferred Routing |
| UPR | Unprocessed Packet Rate |
| UPR | Union Populaire pour la République (French: People's Union for the Republic, Central African Republic) |
| UPR | Upstream Petroleum Report |
| UPR | Unit Performance Record |
| UPR | Uranium Production Reactor |
| UPR | Users' Performance Requirement |