SPOF
| Acronym | Definition |
|---|---|
| SPOF | Single Point of Failure |
| SPOF | Society for the Propagation of the Faith (Catholic Church) |
| SPOF | Science Planning and Operations Facility (ISTP) |
| SPOF | Strategic Plan for Ontario Fisheries (est. 1976; Ministry of Natural Resources; Canada) |
| SPOF | Symmetric Phase Only Filtering |
| SPOF | Screen Printers Open Forum |