SPSU
| Acronym | Definition |
|---|---|
| SPSU | Southern Polytechnic State University (Georgia) |
| SPSU | St. Petersburg State University (Russia) |
| SPSU | State Protection Support Unit (Australian SWAT team) |
| SPSU | Swiss Paediatric Surveillance Unit |
| SPSU | Satellite Processing System Upgrade |
| SPSU | Switching Power Supply Unit |