| Acronym | Definition |
|---|
| SPU | Sripatum University (Thailand) |
| SPU | Signal Processing Unit |
| SPU | Split, Croatia (Airport Code) |
| SPU | Seattle Pacific University |
| SPU | Single Patient Use (medical products) |
| SPU | Sardar Patel University (Vallabh Vidyanagar, Gujarat, India) |
| SPU | Secretaría de Políticas Universitarias (Spanish: Secretariat of University Policies; Argentina) |
| SPU | Seattle Public Utilities |
| SPU | Special Protection Unit (various locations) |
| SPU | Strategy and Policy Unit |
| SPU | Socialist Party of Ukraine |
| SPU | Southern Polytechnic University (Georgia) |
| SPU | Southern Polytechnic University |
| SPU | Segmented Polyurethane |
| SPU | Service Pack Update |
| SPU | Security Processing Unit |
| SPU | Subpicture Decoding Unit |
| SPU | Self Patch Utility |
| SPU | Single Processor Unit |
| SPU | Sound Processing Unit |
| SPU | Synergistic Processor Unit |
| SPU | Special Police Unit |
| SPU | System Processing Unit |
| SPU | Special Purpose Unit |
| SPU | Single Package Unit |
| SPU | Services Processing Unit (computing) |
| SPU | Special Projects Unit (various organizations) |
| SPU | Solar Panel Unit |
| SPU | Somos un Pueblo Unido (Spanish: We Are a United Town; New Mexico) |
| SPU | Short Procedure Unit (various hospitals) |
| SPU | Solids Processing Unit |
| SPU | State Power Utility (India) |
| SPU | Safeguard Policy Update (Asian Development Bank) |
| SPU | Society for Pediatric Urology |
| SPU | Sheep Production Unit |
| SPU | Sound Pick-Up |
| SPU | Super Power Unit |
| SPU | Sub-Picture Unit |
| SPU | Service Production Unit |
| SPU | Specialist, Utility (US Navy) |
| SPU | Secure Processing Unit |
| SPU | Strategic Procurement Unit |
| SPU | Service de Pédagogie Universitaire (French: Department of University Education; University of Namur; Belgium) |
| SPU | Subsystem Power Unit |
| SPU | Socket Power Unit |
| SPU | SAP Processing Unit |
| SPU | Special Planning Unit |
| SPU | S-Band Polar Ultra |
| SPU | Sociedad Peruana de Urología |
| SPU | Simulator Processor Unit |
| SPU | Soybean Processing and Utilization Project (India) |
| SPU | Service Publication Unit |
| SPU | Stage Pré-Universitaire (French: Pre-University Course) |
| SPU | Shard Productions Underground (online video group) |
| SPU | Supra-Phrasal Unit (linguistics) |