SPX
| Acronym | Definition |
|---|---|
| SPX | Standard & Poor's 500 Index |
| SPX | Sequenced Packet Exchange |
| SPX | Small Press Expo |
| SPX | Screen Program |
| SPX | Simplex |
| SPX | Special Effects |
| SPX | Software PBX (Private Branch Exchange) |
| SPX | Sparks, Nevada Bus Station (Amtrak station code; Sparks, NV) |
| SPX | Specialist, Not Elsewhere Classified (US Navy) |
| SPX | Spaceland Airpark (League City, Texas, now defunct) |
| SPX | Sportsinteractive.com |