| Acronym | Definition |
|---|
| TRU | True |
| TRU | Thompson Rivers University (Canada) |
| TRU | Toys R Us |
| TRU | Tomb Raider Underworld (gaming) |
| TRU | Truckee (Amtrak station code; Truckee, CA) |
| TRU | Transuranic |
| TRU | Transceiver Unit |
| TRU | Teenage Research Unlimited |
| TRU | The Root Underground (gaming clan) |
| TRU | Transformer Rectifier Unit |
| TRU | Transuranium |
| TRU | Tolerance, Respect, Understanding |
| TRU | Tactical Response Unit |
| TRU | Time Reference Unit |
| TRU | Tactical Robbery Unit (Miami, FL) |
| TRU | Tha Railroad Undaground (music) |
| TRU | Traditional Rights and Usages |
| TRU | Terminal Respiratory Unit (lung functional unit) |
| TRU | The Real Untouchables (rap group) |
| TRU | Total Return Unitrust |
| TRU | Transmitter/Receiver Unit (cellular systems) |
| TRU | Trujillo, Peru - Trujillo (Airport Code) |
| TRU | Transmit Receive Unit |
| TRU | Technical Rescue Unit |
| TRU | Transitional Rehabilitation Unit |
| TRU | Turbidity Reducing Unit |
| TRU | Thermal Receiving Unit (M1 tank thermal sight) |
| TRU | Thrust Reverser Unit |
| TRU | Total Removed Urea (dialysis) |
| TRU | Trans-Uranic Actinides |
| TRU | Test Replaceable Unit |
| TRU | Technical Resources Unit |
| TRU | Test Repairable Unit |
| TRU | Target Reporting Unit |