| Acronym | Definition |
|---|
| UPD | User Datagram Protocol (computing) |
| UPD | Update |
| UPD | Urban Planning and Design (various schools) |
| UPD | University Police Department |
| UPD | University of the Philippines-Diliman |
| UPD | Uniparental Disomy |
| UPD | Unilateral Price Determination |
| UPD | Universal Printer Driver |
| UPD | Updated Program Data |
| UPD | User Profile Distribution |
| UPD | Unión Progreso y Democracia (Spanish: Union, Progress and Democracy, political party) |
| UPD | User Profile Disk (Microsoft) |
| UPD | Universal Provider Datasource |
| UPD | Union for the Public Domain |
| UPD | Uniform Project Description (US DHHS) |
| UPD | University Professional Development (various schools) |
| UPD | User Profile Database |
| UPD | Under-Potential Deposition |
| UPD | Utah Prairie Dog |
| UPD | Unplanned Dismount |
| UPD | Underwater Propulsion Device |
| UPD | Universal Personal Device |
| UPD | Ulster Project Delaware (est. 1976) |
| UPD | User Performance Data |
| UPD | Univeral Print Driver (Citrix) |
| UPD | Unicorn Protection Device |
| UPD | User Procedure Development |
| UPD | Utah Police Department |
| UPD | Unit Personality Data (Motorola) |
| UPD | University Pizza Deli (Chattanooga, TN) |
| UPD | Unified Prospecting Database (marketing) |
| UPD | Urban Project & Dappa (hip hop band) |
| UPD | Ulrich's Periodical Directory |
| UPD | Unidad Popular Por La Paz, Democracia, Desarrollo y Derechos Humanos (Popular Union for Peace, Democracy, Development and Human Rights; Guatemala) |