| Acronym | Definition |
|---|
| UPE | Urban Planning and Environment (symposium) |
| UPE | Unix Programming Environment |
| UPE | Urban Political Ecology |
| UPE | Universal Primary Education |
| UPE | Universalisation of Primary Education |
| UPE | University of Port Elizabeth (South Africa) |
| UPE | User Portability Extension |
| UPE | Upsilon Pi Epsilon (International Computer Science Honor Society) |
| UPE | Unsuspected Pulmonary Emboli |
| UPE | Unpaid Present Entitlement (financial distribution) |
| UPE | Unreimbursed Partnership Expenses |
| UPE | Universal Plasticx Exchange |
| UPE | User Plane Entity (3GPP) |
| UPE | Ultrasonic Pulse-Echo (for evaluating concrete) |
| UPE | Universiteit van Port Elizabeth (University of Port Elizabeth) |
| UPE | User-Facing Provider Edge (network connection device; also seen as U-PE) |
| UPE | User Portability Extensions |
| UPE | Uniform Programming Environment |
| UPE | User-Facing Premise Equipment (Cisco) |