| Acronym | Definition |
|---|
| US | United States |
| US | United States (top level domain) |
| US | University School (Ohio) |
| US | Under Study |
| US | Up Stage |
| US | Upper School |
| US | Upper Stage |
| US | Universal Studios |
| US | University of Sydney (Sydney, Australia) |
| US | Usual Stuff (polite form) |
| US | Uncle Sam |
| US | University of Saskatchewan |
| US | University of Sussex (UK) |
| US | US Airways |
| US | Upstream |
| US | Universidad de Sevilla (Spain) |
| US | Ultrasound |
| US | Ultimate Six (book) |
| US | Usher Syndrome |
| US | Undersea |
| US | University of Stellenbosch |
| US | United States Supreme Court Decisions |
| US | Ultrasonography |
| US | Unit Specification |
| US | Microsecond |
| US | Unserviceable |
| US | Unconditioned Stimulus (psychology) |
| US | Université de Sherbrooke (Canada) |
| US | Université de Strasbourg (French: University of Strasbourg) |
| US | User Segment |
| US | Unit Strength (gaming) |
| US | Unit Separator |
| US | Underspeed (US Space Program) |
| US | Université du Sud (French: University of the South) |
| US | Universiteit van Stellenbosch (University of Stellenbosch) |
| US | Ut Supra (Latin: As Above) |
| US | Freedom Union (Czech Republic) |
| US | Ubi Supra (Latin: Where Above Mentioned) |
| US | Utilisateurs Simultanés (Informatique) |
| US | Uniwersytet Szczecinski (Polish: University of Szczecin) |
| US | United Soldiers (Raven Shield gaming clan) |
| US | Underwriting Screen (insurance) |
| US | Unitary Symmetry |
| US | Université Savoie (France) |
| US | UberSoft, Inc. |