| Acronym | Definition |
|---|
| APSE | Associated Press Sports Editors (Dallas, Texas) |
| APSE | Association for Persons in Supported Employment |
| APSE | Association for Public Service Excellence (Manchester, UK) |
| APSE | Ada Programming Support Environment |
| APSE | Asociación para la Promoción de la Seguridad Eléctrica (association for promotion of electrical security, Buenos Aires, Argentina) |
| APSE | Asociación de Profesores de Segunda Enseñanza (association of teachers for second-chance education, Costa Rica) |
| APSE | Alternative Pathway to Secondary Education (Jamaica) |
| APSE | AGFA Publishing Systems Environment |
| APSE | Armour Piercing Secondary Effect |