| Acronym | Definition |
|---|
| WIRE | File Extension (Alias wireframe file extension) |
| WIRE | World-wide Information System for Renewable Energy |
| WIRE | Women in Rural Enterprise (UK) |
| WIRE | Women in Real Estate |
| WIRE | Wide-Field Infrared Explorer (satellite) |
| WIRE | Wolverhampton Intellectual Repository and E-Theses (University of Wolverhampton; UK) |
| WIRE | Women's Information and Referral Exchange |
| WIRE | Whidbey Island Rescue for Equines |
| WIRE | Workplace Internal Regulatory Establishment (United Arab Emirates) |
| WIRE | Women Investing in Real Estate (Duncanville, TX) |
| WIRE | Widearea Infrared Explorer |
| WIRE | Western Installation Requirements Evaluation |
| WIRE | Wireless Internet Research and Engineering Laboratory (National Tsing Hua University; Taiwan) |
| WIRE | Weapon Interference Reduction Effort |