| Acronym | Definition |
|---|
| WIS | Wisdom |
| WIS | Wisconsin (old style) |
| WIS | Washington International School |
| WIS | Writers in Schools (various locations) |
| WIS | Weizmann Institute of Science |
| WIS | Women in Science |
| WIS | Worldwide Information System |
| WIS | Wireless Intel Speedstep |
| WIS | Wireless Internet Server |
| WIS | Water-Insoluble Solid (biomass) |
| WIS | Workshop Information System (automotive industry) |
| WIS | Wellesley Information Services |
| WIS | Washington Inventory Service |
| WIS | WAN Interface Sublayer |
| WIS | Wachovia Insurance Services, Inc. (now Wells Fargo Insurance Services USA) |
| WIS | Windows Installer Service |
| WIS | Web Information System |
| WIS | WWMCCS Information System |
| WIS | Wonderful Iodine State (South Carolina) |
| WIS | Waseda International School (Japan) |
| WIS | Walsh Intermediate School (Branford, CT) |
| WIS | Wehrwissenschaftliches Institut für Schutztechnologien (CBRN-defence Agency of the federal German Armament Division) |
| WIS | Wroclaw International School (Poland) |
| WIS | Watch Idiot Savant |
| WIS | Werkzoekende Informatie Systeem (Dutch: Jobseeker Information System) |
| WIS | Worldwide Industrial Seaming |
| WIS | Wedge Imaging Spectrometer |
| WIS | Wagon Investment Scheme (Indian Railways) |
| WIS | Workforce Investment Systems |
| WIS | World Institute of Science |
| WIS | Weapon Information System |
| WIS | Work in Submission |
| WIS | World Interact System (company, Budapest Hungary) |
| WIS | Weapons Interface Subsystem |
| WIS | World Intelligence Summary (US DIA) |
| WIS | Wireless Industry Standards |
| WIS | WFP (World Food Programme) Information System (UN) |