| Acronym | Definition |
|---|
| WPE | Women's Protection and Empowerment (International Rescue Committee) |
| WPE | Web Publishing Engine |
| WPE | Windows Protected Environment |
| WPE | Windows Preinstallation Environment |
| WPE | Web Public Education |
| WPE | Windows Packet Editor |
| WPE | Worldwide Publishing Enterprises |
| WPE | Windows Password Expert |
| WPE | Web and Pervasive Environments |
| WPE | Wall-Plug Efficiency |
| WPE | Writing Proficiency Exam |
| WPE | Work Performance Evaluation |
| WPE | Water Plant Emulsion (processing technology) |
| WPE | Word Processing Equipment |
| WPE | Weight Per Epoxide |
| WPE | Well Proximity Effect |
| WPE | World Parliament Experiment (online debating forum) |
| WPE | Winsock Packet Editor |
| WPE | Worst President Ever |
| WPE | Worst Person Ever |
| WPE | Wakil Perusahaan Efek (Indonesian: Securities Companies Representatives) |
| WPE | Walker Process Equipment (Aurora, IL) |
| WPE | Workpackage Exchange |
| WPE | Williams Precision Engines |
| WPE | Weight, Power, EVA |
| WPE | Whole Product Element |