| Acronym | Definition |
|---|
| VPL | Vancouver Public Library |
| VPL | Valor Presente Liquido (Portuguese: Net Present Value) |
| VPL | Visible Panty Line |
| VPL | Veterinary Products Laboratories |
| VPL | Video Projector Line |
| VPL | Visual Programming Language |
| VPL | Vertical Protection Level |
| VPL | Victoria Public Library (various locations) |
| VPL | Virtual Path Link |
| VPL | Vineland Public Library (Vineland, NJ) |
| VPL | Virtual Planetary Laboratory |
| VPL | Ventral Posterolateral Nucleus (brain) |
| VPL | Virtual Private LAN |
| VPL | Virtual Prescriptive Learning (educational software) |
| VPL | Virtual Private Line |
| VPL | Visible Penis Line |
| VPL | Vanco Prykerchenska Ltd. (est. 2007; Vanco Energy Company) |
| VPL | Vernon Public Library (Canada) |
| VPL | Vertical Plane Launch (wide-band model) |
| VPL | Vibrant Parish Life |
| VPL | Voltage Protection Level |
| VPL | Vanishing Point Left |
| VPL | Visual Perception Laboratory (Rochester Institute of Technology) |
| VPL | Virtual Processing Laboratory |
| VPL | Vega Precision Laboratories, Inc. |