| Acronym | Definition |
|---|
| WDE | Walt Disney Enterprises (entertainment) |
| WDE | World Domination Enterprises (rock band) |
| WDE | Web Data Extractor |
| WDE | Wide Dynamic Execution |
| WDE | Whole Disk Encryption (PGP Desktop) |
| WDE | Worst Defense Ever |
| WDE | Windows Double Explorer (software) |
| WDE | Westinghouse Digital Electronics |
| WDE | Wheel Drive Electronics |
| WDE | War Damn Eagle (Auburn University Tigers) |
| WDE | Worst Day Ever |
| WDE | Workforce Development and Education (Ohio State University) |
| WDE | The Widecom Group, Inc. (former stock symbol; now WIDEE) |
| WDE | Waveform Development Environment |
| WDE | Web-based Design Environment |
| WDE | Wood Drying Engineering (Italy) |
| WDE | Wavelength Drop Edge |
| WDE | Weapons Directing Equipment |
| WDE | Wireless Data Enhancer (Nokia WDSS) |
| WDE | Wax Deposition Envelope |