| Acronym | Definition |
|---|
| VRU | Voice Response Unit |
| VRU | Virtual Response Unit |
| VRU | Vapor Recovery Unit |
| VRU | Venus Resources Unlimited (gaming clan) |
| VRU | Voice Recognition Unit |
| VRU | Vulnerable Road User |
| VRU | Voie Rapide Urbaine (French: Urban Fast Lane; highway) |
| VRU | Virginia Rugby Union |
| VRU | Transport Utility Squadron (US Navy) |
| VRU | Vacuum Recovery Unit (US Navy) |
| VRU | Vertical Reference Unit |
| VRU | Vancouver Rugby Union (Vancouver, BC, Canada) |
| VRU | Vocal Response Unit (band) |
| VRU | Virtual Resource Unit |
| VRU | Vessel Reference Unit (maritime dynamic positioning systems) |
| VRU | Virology Research Unit (International Center for Tropical Agriculture; Colombia) |
| VRU | Virtual Readiness University |