| Acronym | Definition |
|---|
| VSD | Ventricular Septal Defect |
| VSD | Visio (file extension) |
| VSD | Vail School District (Arizona) |
| VSD | Variable Speed Drive |
| VSD | Vaccine Safety Datalink |
| VSD | Virus Signature Database (antivirus software) |
| VSD | Voltage Sensitive Dye (imaging) |
| VSD | Vehicle Safety Device |
| VSD | Valley Sanitary District (various locations) |
| VSD | Vernonia School District (Oregon) |
| VSD | Vascular-Streak Dieback (disease) |
| VSD | Visual Studio for Devices |
| VSD | Vendor Specific Driver |
| VSD | Validation of Digitally Signed Document |
| VSD | Virus Description |
| VSD | Virtual Speaker Driver |
| VSD | via Secondary Device |
| VSD | Visio Document |
| VSD | Virtual System Driver |
| VSD | Variable Sized Droplet |
| VSD | Variable Size Dot |
| VSD | Visio Drawing |
| VSD | Vidéo sur Demande (French: Video on Demand) |
| VSD | Video Smoke Detection |
| VSD | Value Sensitive Design |
| VSD | Vertical Situation Display |
| VSD | Vertical Situation Display (F-15 CTVS) |
| VSD | Very Strongly Disagree (survey response) |
| VSD | Virtualized Software Development (Virtutech, Inc.) |
| VSD | Virtually Safe Dose |
| VSD | Vendredi Samedi Dimanche (French news magazine) |
| VSD | Virtual Shared Disk |
| VSD | Victory-class Star Destroyer (Star Wars) |
| VSD | Video Slave Driver (digital sync device) |
| VSD | Volunteer San Diego (San Diego, CA) |
| VSD | Visible Surface Determination (3D graphics) |
| VSD | Veterinary Services Department |
| VSD | Visual Systems Division |
| VSD | Voluntary Self Disclosure |
| VSD | Veterinary Science Division (Scottish Agricultural College) |
| VSD | Source Drain Voltage |
| VSD | Vendor Supplied Driver |
| VSD | Visual Studio Debugger |
| VSD | Veterans Services Division |
| VSD | Variable Slope Delta |
| VSD | Variable Speed Drogue (aerial refueling) |
| VSD | Vulcan Science Directorate (Star Trek: Enterprise) |
| VSD | Vector Symbol Decoding |
| VSD | Vendor's Shipping Document |
| VSD | Valve Status Diagram |
| VSD | Virtual System Environment |
| VSD | Van Speciale Diensten (Dutch) |
| VSD | Vitesse de Sécurité au Décollage (French: Takeoff Safety Speed) |
| VSD | Virtual Shared DASD (IBM) |
| VSD | Voice Service Delivery (used in provisioning circuits) |
| VSD | Vestibular System Disorder |
| VSD | Vykon Tridium Distributor (energy control services) |