| Acronym | Definition |
|---|
| VSE | Vision for Space Exploration |
| VSE | Vancouver Stock Exchange (British Columbia, Canada) |
| VSE | Visual Space Enhancer |
| VSE | Vertex Shader Engine |
| VSE | Virus Scan Engine |
| VSE | Virtual System Extensions |
| VSE | Virtual Server Environment |
| VSE | Virus Scan Enterprise |
| VSE | Vertical Size Extension |
| VSE | Virtual Storage Extended |
| VSE | Voluntary Support of Education (survey) |
| VSE | Vilnius Stock Exchange (Lithuania) |
| VSE | Verification Support Environment |
| VSE | Virtual Service Environment |
| VSE | Vertical Search Engine (Watt4) |
| VSE | Vysoka Skola Ekonomicka (University of Economics in Prague, Czech Republic) |
| VSE | Very Small Enterprise |
| VSE | Versatile Service Engine |
| VSE | Vienna Special Edition (sound library) |
| VSE | Vegan Straight Edge (lifestyle) |
| VSE | Vancomycin Sensitive Enterococcus |
| VSE | Vintage Synth Explorer |
| VSE | Violence Solves Everything (gaming clan) |
| VSE | Visual Surveillance of Extremities |
| VSE | Voice Services Equipment (telephony) |
| VSE | Vehicle Systems Engineer (automotive) |
| VSE | Vivaldi Slot Element (antenna) |
| VSE | Village and Small Enterprises (India) |
| VSE | Veritas Sequitur Esse (Latin: truth follows the existence of things) |
| VSE | Video Switching Equipment |
| VSE | Voice Switch Engineering |