| Acronym | Definition |
|---|
| XR | Extended-Release (pharmaceuticals) |
| XR | X-Ray |
| XR | Exchange Rate (currency) |
| XR | Cross-Reference |
| XR | Extinction Rebellion (activist organization) |
| XR | Extended Range |
| XR | Xref (assembly language ASM51 assembler control) |
| XR | Crossroads |
| XR | X-Linked Recessive (skin condition) |
| XR | Experimental Research (Ford Motor Company) |
| XR | Jesus Christ (from first 2 letters of Greek Christos; archaic) |
| XR | Xtreme Revolution (gaming) |
| XR | External Reset |
| XR | Experimental Rocket |
| XR | Exceptional Requirements (Maricopa County, AZ community college system) |
| XR | Export Reactor |