| Acronym | Definition |
|---|
| BIG | Believe In God |
| BIG | Blacks In Government |
| BIG | Best in Group |
| BIG | Badan Informasi Geospasial (Indonesian: Geospatial Information Agency) |
| BIG | Bjarke Ingels Group (Copenhagen, Denmark) |
| BIG | Balm in Gilead |
| BIG | Babcock International Group (UK) |
| BIG | Beijing Institute of Genomics (China) |
| BIG | Breast International Group (Belgium) |
| BIG | Berlin International Gaming (Berlin, Germany) |
| BIG | Baltimore Improv Group (Baltimore, MD) |
| BIG | Best in Game |
| BIG | Basel Institute on Governance (Basel, Switzerland) |
| BIG | Boycott Israeli Goods |
| BIG | Business Information Group |
| BIG | Biomedical Imaging Group (various locations) |
| BIG | Best Impact Graphics |
| BIG | Binary Image Group |
| BIG | Broadband-in-Gas (wireless communications) |
| BIG | Blind Idiot God (instrumental band) |
| BIG | Boating Infrastructure Grant |
| BIG | Bremer Investitions Gesellschaft (German: Bremer Investment Company) |
| BIG | Big Mat - Auber 93 (Tour de France cycling sponsor) |
| BIG | Biker Information Guide (various locations) |
| BIG | Broad Investment Grade (finance) |
| BIG | Balboa Insurance Group (Irvine, CA) |
| BIG | Business Interest Group |
| BIG | Born in Game (gaming; The Sims 2) |
| BIG | Books Instead of Guns |
| BIG | Brand Identity Guru Inc. (web design) |
| BIG | Bond Investors Guaranty |
| BIG | Broadband Internet Gateway |
| BIG | Blackland Income Growth (Texas) |
| BIG | Botulinum Immune Globulin |
| BIG | Biarritz International Groove (music festival; France) |
| BIG | Biological Isolation Garment (US NASA) |
| BIG | Bionet Intelligent Gateway (Biodata) |
| BIG | Burlington International Games |
| BIG | Bold in God |
| BIG | Business Instead of Games (rapper) |
| BIG | Bentley Investment Group (Bentley College) |
| BIG | Brandweer Informatiecentrum Gevaarlijke Stoffen (Dutch: Hazardous Substances Information Center; Belgium) |
| BIG | Blocking Island Graph (Zhemin/Hamdi) |
| BIG | Business Integration Gateway |
| BIG | Back-Inlet Gully (British building industry) |
| BIG | Billing Improvement Group (Sprint) |
| BIG | Bubble Investment Group |
| BIG | Butterfly Interest Group Nature Society (Singapore) |
| BIG | Business, Industry and Government Club (Harvard Business School) |