| Acronym | Definition |
|---|
| ACME | Activity Monitor |
| ACME | Assembling Configuration Management Environment |
| ACME | Advanced Computer Matrix for Engineering |
| ACME | Action Coalition for Media Education (Albuquerque, NM) |
| ACME | Advisory Committee on Mathematics Education |
| ACME | Arms Control in the Middle East (talks; various nations) |
| ACME | Association for Convention Marketing Executives |
| ACME | Aerospace, Civil and Mechanical Engineering (department) |
| ACME | Advisory Committee on the Marine Environment |
| ACME | Association of Consulting Management Engineers |
| ACME | Assembling Configuration Management Environments (software development) |
| ACME | Application of Commercially Manufactured Electronics |
| ACME | Advanced Cosmic Microwave Explorer (satellite) |
| ACME | Adaptive Collection Management Environment |
| ACME | Applications of Computers to Manufacturing Engineering |
| ACME | Annual Conference of Managing Editors |
| ACME | Actively Conserving Marysville Environs |
| ACME | Alumni Council of Middle East |
| ACME | Air Crew Combat Mission Enhancement |
| ACME | Automated Contractual Minimal Enhancements (Sprint) |
| ACME | Authentication Credential Management Extension (authentication subsystem, OpenVMS HP Corporation) |
| ACME | Airborne Cloud Measurement Equipment |