| Acronym | Definition |
|---|
| CASTLE | Computer Aided Systems for Teacher Led Education |
| CASTLE | Controls Analysis and Simulation Test Loop Environment |
| CASTLE | Carcinoma Showing Thymus Like Differentiation |
| CASTLE | Capacitor-Aided System for Teaching and Learning Electricity |
| CASTLE | Citadel Academy for the Scholarship of Teaching, Learning, and Evaluation (Charleston, SC) |
| CASTLE | Computer-Assisted System for Theater Level Engineering |
| CASTLE | Communicative and Supportive Teaching/Learning Environment |
| CASTLE | Connecting A Student To Lifelong Education |