| Acronym | Definition |
|---|
| CAFE | Corporate Average Fuel Economy |
| CAFE | Clean Air for Europe |
| CAFE | Component Application Framework for Enterprise |
| CAFE | Cannabis and Fine Edibles (Toronto, Ontario, Canada) |
| CAFE | Host America Corporation (stock symbol; formerly HAC) |
| CAFE | Conventional Armed Forces in Europe |
| CAFE | Comparative Aircraft Flight Efficiency Foundation (California) |
| CAFE | Canadian Association of Family Enterprises (Kingston, ON, Canada) |
| CAFE | Consolidated Application Foundation for Eclipse (Java development) |
| CAFE | Conditional Access for Europe (electronic payment system) |
| CAFE | Conduit Artery Function Evaluation |
| CAFE | Ciudadanos Activos de Formación Electoral (Spanish: Active Citizens Electoral Training; Guatemala) |
| CAFE | Conservatives Against a Federal Europe (UK) |
| CAFE | Camaradas, Arriba Falange Española! (Spanish political slogan) |
| CAFE | Coffee and Farmer Equality |
| CAFE | Ciències de l'Activitat Física I l'Esport (Catalonia) |
| CAFE | Community Alliance of the Far Eastside (Indiana) |
| CAFE | Communications Access for Everyone |
| CAFE | Concepts to Application in System-Family Engineering |
| CAFE | Computer Algebra & Functional Equations |
| CAFE | Communications Automation Follow-On Effort |
| CAFE | Central Australian Fronts Experiment |
| CAFE | Clarity Audio Front End |
| CAFE | Canadian Association of Fairs & Expositions |
| CAFE | Canadian Association of Fish Exporters |
| CAFE | Collateral Artery Flow Exercises |