| Acronym | Definition |
|---|
| CROSS | Customs Rulings Online Search System (US Customs and Border Protection searchable database) |
| CROSS | Cross Support Service |
| CROSS | Centres Regionaux Operationnels de Surveillance et de Sauvetage |
| CROSS | Comité Régional de l'Organisation Sanitaire et Sociale |
| CROSS | Church Related Online Software Systems |
| CROSS | Committee to Retain Our Segregated Schools (1950s segregationist group) |
| CROSS | Commission Régionale d'Organisation du Système Sanitaire |
| CROSS | Core Router Operating System Support |
| CROSS | Christians Reaching Out Spreading Spirituality |
| CROSS | Christian Rock Operatic Symphonic Songs (music genre) |