| Acronym | Definition |
|---|
| DEST | Destination |
| DEST | Department of Education, Science and Training (Australia) |
| DEST | Destroy |
| DEST | Domestic Emergency Support Team (FBI/FEMA) |
| DEST | Digital Ecosystems and Technologies (conference) |
| DEST | Department of the Environment, Sport and Territories (Australia) |
| DEST | Diplôme d'Etudes Supérieures Technologiques (French: Technological Higher Education Diploma) |
| DEST | Deaf Enhanced Support Team |
| DEST | Draconis Elite Strike Teams (Battletech) |
| DEST | Directed Energy Science and Technology |
| DEST | Denver Eye Screening Test (Denver Developmental Materials, Inc.) |