| Acronym | Definition |
|---|
| EN | English |
| EN | Entertainment News |
| EN | English Nature (UK) |
| EN | Enemy |
| EN | Engineer |
| EN | Estonia |
| EN | Enterprise Network |
| EN | Electronic News |
| EN | Enhancement |
| EN | El Niño |
| EN | Endurance |
| EN | Endangered (IUCN Red List of Threatened Species category) |
| EN | Equipment Number |
| EN | European Standard (market standards) |
| EN | Enfield (postcode, United Kingdom) |
| EN | Employment Networks (Social Security Administration) |
| EN | End Node |
| EN | Express Network |
| EN | Eternal Night (gaming) |
| EN | European Norm |
| EN | Enrolled Nurse |
| EN | Air Dolomiti (Airline Code) |
| EN | Einstürzende Neubauten (German industrial band) |
| EN | Electronegativity |
| EN | Enteral Nutrition |
| EN | Endurance Nation (online triathletes' resource) |
| EN | Ethylenediamine (chemistry) |
| EN | Evangelii Nuntiandi (On Evangelism in the Modern World) |
| EN | Empty Netter (ice hockey) |
| EN | Estrada Nacional (Portugal) |
| EN | Electronic Notebook |
| EN | Enna, Sicilia (Italian province) |
| EN | Emergency Notice (NANPA) |
| EN | Emerald Nuts |
| EN | Extension Node |
| EN | Exception Notice (ITI) |
| EN | Esquerda Nacionalista (Galician political party) |
| EN | Evaluation Notice (US government) |
| EN | Esquimalt and Nanaimo Railway (Canadian railroad company) |
| EN | Engineering Notice |
| EN | Electronic Neutralization |
| EN | Emitter Number |
| EN | ELINT Notation |
| EN | Electrical Notebook |
| EN | Elektronegativitat(German) |
| EN | (USN Rating) Engineman |