| Acronym | Definition |
|---|
| D&D | Dungeons and Dragons |
| D&D | Design & Development |
| D&D | Dean & Deluca |
| D&D | Drag and Drop (mouse interface) |
| D&D | Dumb and Dumber (movie) |
| D&D | Deaf and Dumb |
| D&D | Deities and Demigods |
| D&D | Denial and Deception (US DoD) |
| D&D | Deuterium Deuterium |
| D&D | Decontamination and Decommissioning |
| D&D | Death & Disability (insurance coverage) |
| D&D | Drag and Drop |
| D&D | Death and Dismemberment |
| D&D | Drunk and Disorderly |
| D&D | Drug and Disease |
| D&D | Dishwasher and Disposal |
| D&D | Done and Dusted |
| D&D | Deactivation and Decommissioning |
| D&D | Detection and Direction |
| D&D | Delay and Disruption |
| D&D | Degen & Degen Architecture and Interior Design (various locations) |
| D&D | Damage & Destroy |
| D&D | Distress and Diversion |
| D&D | Devonshire and Dorset Regiment (British regiment) |
| D&D | Divorced & Desperate |
| D&D | Diversity and Dialogue (Norway and UK) |
| D&D | Display & Decision (Area) |
| D&D | Divestiture & Deregulation |
| D&D | Distress & Disaster |
| D&D | Diu and Damman (India) |