| Acronym | Definition |
|---|
| D3 | Doom 3 (game) |
| D3 | Diablo 3 (gaming) |
| D3 | Data-Driven Decision-Making |
| D3 | Dirty Three (Australian band) |
| D3 | Detroit 3 (North American Automobile Manufacturing) |
| D3 | Descent III (computer game) |
| D3 | Dynamic Document Drafting (Microsystems software) |
| D3 | 3-Sided Dice (gaming) |
| D3 | Design, Development & Documentation |
| D3 | Direct-Data Domain (least squares method) |
| D3 | Third Generation Channel Bank (24 Channels on T1) |
| D3 | Degrade, Disrupt, Deny |
| D3 | Direct Data Distribution |
| D3 | Defending the Digital Domain |
| D3 | Decide, Detect, and Deliver |
| D3 | Device Mode 3 (full-off power state, computing) |