| Acronym | Definition |
|---|
| DDE | Dynamic Data Exchange |
| DDE | Dade City (Amtrak station code; Dade City, FL) |
| DDE | Direction Departementale de l'Equipement |
| DDE | Doctrine of Double Effect (healthcare) |
| DDE | Direct Data Entry |
| DDE | Diploma in Distance Education |
| DDE | Daily Driven Exotics |
| DDE | Distributed Discrete Event (computing) |
| DDE | Demand Data Exchange (US DoD) |
| DDE | Dichlorodiphenyldichloroethylene |
| DDE | Diocesan Director of Education (various organizations) |
| DDE | Design and Development Engineering |
| DDE | Digital Diesel Electronics |
| DDE | Dolby Digital Encoding |
| DDE | Daylight Demon Eyes (auto headlights) |
| DDE | Dwight David Eisenhower (34th President of the USA) |
| DDE | Delay Differential Equation(s) |
| DDE | Displacement Damage Effect |
| DDE | Detail Design Engineering (UK) |
| DDE | Direct Data Exchange |
| DDE | Escort Destroyer (post-war DD conversion) |
| DDE | Deep Dose Equivalent |
| DDE | Department of Distance Education |
| DDE | Double Data Entry |
| DDE | Dichlorodiphenylethylene |
| DDE | Deputy District Engineer (USACE) |
| DDE | Device-Dependent Error (SESR bit - GPIB) |
| DDE | Dirty Disc Error (Xbox) |
| DDE | Data Distribution Equipment |
| DDE | Digital Definition Exchange |
| DDE | Data Dictionary Entry |
| DDE | Directional Derivative Estimator |
| DDE | DuPont Dai Nippon Engineering (joint partnership between DuPont Photomasks and Dai Nippon Printing Co., Ltd.) |
| DDE | Drug Dictionary Enhanced (Uppsala Monitoring Centre; Sweden) |
| DDE | Daniel Displacement Engine (satellite station keeping) |
| DDE | Designated Doctor Evaluation |