| Acronym | Definition |
|---|
| DDI | Didanosine (aka Videx; antiretroviral drug) |
| DDI | Data Documentation Initiative |
| DDI | Development Dimensions International, Inc. |
| DDI | Direction et Développement Informatique (French: Management and Software Development) |
| DDI | Dideoxyinosine |
| DDI | Dedicated Display Interface |
| DDI | Display Driver Interface |
| DDI | Disk Doubler Image |
| DDI | Digital Data Interchange |
| DDI | Direct Data Interface |
| DDI | Distributed Data Interface |
| DDI | Direct Draw Interface |
| DDI | Data Distribution Initiative |
| DDI | Disk Dupe Image |
| DDI | Device Driver Interface |
| DDI | Déclaration des Droits de l'Internaute (French: Declaration of Internet Rights) |
| DDI | Direct Dialing In |
| DDI | Drug-Drug Interaction |
| DDI | Diplôme de Docteur Ingénieur (French: Doctorate of Engineering; various universities) |
| DDI | Data Design Interactive (video game developer; UK) |
| DDI | Dansk Døve-Idrætsforbund |
| DDI | Design Driven Innovation (networking blog) |
| DDI | Direct Debit Instruction (UK finance & banking term) |
| DDI | Development, Design and Implementation (various organizations) |
| DDI | Deputy Director of Intelligence (US CIA) |
| DDI | Don't Do It |
| DDI | Développement et Distribution Informatique (French: Information Distribution and Development; Belgium) |
| DDI | Duke Digital Initiative (Duke University) |
| DDI | Direct Debit Instruction |
| DDI | Discado Directo Internacional (Spanish: international direct dial) |
| DDI | Discagem Direta Internacional (Brazilian Portuguese: direct international dialing) |
| DDI | Dynamic Desktop Initiative (software; CItrix) |
| DDI | Distressed Debt Investors |
| DDI | Device Dependent Interface |
| DDI | Digital Display Indicator |
| DDI | Design, Develop, and Implement |
| DDI | Douai Distribution Industrielle (French distribution company) |
| DDI | Dairy Development International, LLC |
| DDI | Data Directions Inc. (Virginia) |
| DDI | Diagnostic Digital Imaging |
| DDI | Deutsches Derivate Institut (German: German Derivatives Institute) |
| DDI | Data and Dimensions Interface |
| DDI | Director of Defense Information |
| DDI | Dartmouth Debate Institute |
| DDI | Downwelling Diffuse Irradiance (clouds) |
| DDI | Día de Independencia (Spanish: Independence Day) |
| DDI | Direct Deposit Indicator |
| DDI | Digital Data Interpreter |
| DDI | Distilled De-Ionized (water) |
| DDI | Digital Data Indicator |
| DDI | Depth Deviation Indicator |
| DDI | Duty Director for Intelligence |
| DDI | Discrete Data Input (NASA) |
| DDI | Database Data Interchange |
| DDI | Dedicated Display Indicator (NASA) |
| DDI | Director Defense Information |
| DDI | Discrete Digital Input |
| DDI | Dummy, Drill and Inert (training ammunition) |
| DDI | Document Data Index (configuration management) |
| DDI | Decoy-DECM Integration |
| DDI | Dynamic Dies, Inc. (est. 1971) |
| DDI | Dynamic Data Interchange |
| DDI | Dental Digital Imaging (dentistry) |
| DDI | Database Designing Incorporated |
| DDI | Diamond Design, Inc. |
| DDI | Demand Display Index |
| DDI | Direct Dial Information |
| DDI | Daini-Denden Planning Company (Japan, now KDDI) |
| DDI | Drivers Display Interface |
| DDI | Digital Design Initiative |