| Acronym | Definition |
|---|
| ESPN | Entertainment and Sports Programming Network |
| ESPN | East Penn Railroad (Kennett Square, PA) |
| ESPN | Economic, Social, Political, Environmental |
| ESPN | European Society for Paediatric Nephrology (est. 1967) |
| ESPN | Enological Society of the Pacific Northwest (wine enthusiasts' organization) |
| ESPN | European Society for Pediatric Neurosurgery (est. 1967) |
| ESPN | Équipements sous Pression Nucléaires (French: Equipment Under Nuclear Pressure) |
| ESPN | Extended Stochastic Petri Net (mathematical engineering) |
| ESPN | Eastside Suburban Peace Network (Seattle, WA) |